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September-December 2012 Volume 11 | Issue 3
Page Nos. 99-200
Online since Saturday, November 10, 2012
Accessed 47,548 times.
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EDITORIALS |
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When was the Last Time You did Something for the First Time?  |
p. 99 |
Ajit Kumar Padhy DOI:10.4103/1450-1147.103404 PMID:23372444 |
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Nuclear Medicine in Finland |
p. 101 |
Kalevi Kairemo DOI:10.4103/1450-1147.103406 PMID:23372445 |
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Global WARMTH for Patients with Cancer |
p. 103 |
J Harvey Turner DOI:10.4103/1450-1147.103407 PMID:23372446 |
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ORIGINAL ARTICLES |
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Standard Operating Procedure for In-house Preparation of 131 I-rituximab for Radioimmunotherapy of Non-Hodgkin's Lymphoma |
p. 105 |
Matthew D Pickford, J Harvey Turner DOI:10.4103/1450-1147.103408 PMID:23372447A Standard Operating Procedure (SOP) has been formulated for in-house preparation, quality control, dispensing and administration of 131 I-rituximab appropriate for the safe, effective, radioimmunotherapy of non-Hodgkin lymphoma. A decade of experience of semi-automated radioiodination of rituximab in our hospital radiopharmaceutical laboratory was analysed. The methodology was then refined for safe, practical, affordable application to radioimmunotherapy of lymphoma in departments of nuclear medicine in developing countries. This SOP has the potential to be incorporated into good laboratory practice conditions appropriate for local regulatory agency requirements. |
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Standard Operating Procedure for Prospective Individualised Dosimetry for [131] I-rituximab Radioimmunotherapy of Non-Hodgkin's Lymphoma |
p. 110 |
Phillipe J Calais, J Harvey Turner DOI:10.4103/1450-1147.103409 PMID:23372448Radioimmunotherapy (RIT) is an attractive therapy for non-Hodgkin's lymphoma (NHL) as it allows targeted tumor irradiation which provides a cytotoxic effect significantly greater than that of the immune-mediated effects of a non-radioactive, or 'cold', antibody alone. Anti-CD20 antibodies such as rituximab are ideal for RIT, as not only is it easily iodinated, but the CD20 antigen is found on more than 95% of B-cell NHL. A standard operating procedure (SOP) has been formulated for personalized prospective dosimetry for safe, effective outpatient 131 I-rituximab RIT of NHL. Over five years, experience of treatment of outpatients with 131 I-rituximab was analyzed with respect to critical organ radiation dose in patients and radiation exposure of their carers. This radiation safety methodology has been refined; and offers the potential for safe, practical application to outpatient 131 I-rituximab RIT of lymphoma in general and in developing countries in particular. Given endorsement and sanction of this SOP by local regulatory authorities the personalized dosimetry paradigm will facilitate incorporation of RIT into the routine clinical practice of therapeutic nuclear oncology worldwide. |
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ABSTRACTS |
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Warmth 7th International Conference on Radiopharmaceutical Therapy (Icrt 2012) Levi, Finland |
p. 117 |
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Pre-conference Symposium on Nuclear Cardiology |
p. 118 |
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ICRT-Speakers' Abstracts |
p. 121 |
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ICRT-Abstracts of Oral Presentations |
p. 154 |
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ICRT-Abstracts of Poster Presentations |
p. 160 |
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