World Journal of Nuclear Medicine

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 20  |  Issue : 2  |  Page : 145--149

Evaluation of myocardial perfusion and function in patients with asymptomatic beta-thalassemia major using myocardial gated single-photon-emission computed tomography


Abdolmajid Omrani1, Parivash Rahimzadeh1, Ali Aba2, Esmail Jafari3, Abdullatif Amini4, Majid Assadi3 
1 Department of Pediatrics , Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
2 Jam Tohid Hospital, Bushehr Province, Bushehr, Iran
3 The Persian Gulf Nuclear Medicine Research Center, Department of Molecular Imaging and Radionuclide Therapy (MIRT), Bushehr Medical University Hospital, Bushehr University of Medical Sciences, Bushehr, Iran
4 Bushehr Heart Medical Center, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran

Correspondence Address:
Prof. Majid Assadi
The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr
Iran

This study was conducted to evaluate the cardiac perfusion and function of patients with beta-thalassemia major (TM) using99mTc-MIBI cardiac gated single-photon-emission computed tomography (SPECT) and to compare the obtained indices with echocardiographic and hematological parameters. Patients with TM who were referred for regular blood transfusion and periodic checkup were included in this study. A questionnaire containing demographic and medical data was provided for all patients by an expert pediatrician. All of the patients were on Desferal chelation therapy and none of them had clinical signs of heart failure. Myocardial gated perfusion SPECT, echocardiography, and complete blood tests were performed for each patient. In total, 24 patients including 14 men (58.3%) and 10 women (41.7%) aged 15–36 years with a mean age of 24.3 ± 6.5 years' old were enrolled in this study. Myocardial perfusion scan (MPS) was normal in all patients. The mean value of the measured left ventricular ejection fraction (LVEF) was 58.88 ± 13.45%. There was no significant association between measured LVEF on scan and echocardiography (P > 0.05). In terms of hematological results, there was a significant association between the hemoglobin and ferritin level and the amount of blood transfusion (P = 0.02 and P= 0.00, respectively). According to the results of myocardial perfusion imaging (MPI), cardiac perfusion and LVEF were within normal limits in all asymptomatic patients. In the absence of any perfusion abnormality, the use of MPI in patients with asymptomatic beta-TM is not recommended for diagnosing myocardial ischemia.


How to cite this article:
Omrani A, Rahimzadeh P, Aba A, Jafari E, Amini A, Assadi M. Evaluation of myocardial perfusion and function in patients with asymptomatic beta-thalassemia major using myocardial gated single-photon-emission computed tomography.World J Nucl Med 2021;20:145-149


How to cite this URL:
Omrani A, Rahimzadeh P, Aba A, Jafari E, Amini A, Assadi M. Evaluation of myocardial perfusion and function in patients with asymptomatic beta-thalassemia major using myocardial gated single-photon-emission computed tomography. World J Nucl Med [serial online] 2021 [cited 2021 Jun 25 ];20:145-149
Available from: http://www.wjnm.org/article.asp?issn=1450-1147;year=2021;volume=20;issue=2;spage=145;epage=149;aulast=Omrani;type=0