World Journal of Nuclear Medicine

CASE REPORT
Year
: 2013  |  Volume : 12  |  Issue : 3  |  Page : 116--119

Technetium-99m-methylene Diphosphonate Uptake in Hepatic Necrosis Secondary to Respiratory Failure


Madhuri Shimpi Mahajan, Negi S Digamber, Rajkumar Sharma 
 Department of Nuclear Medicine, Saral Diagnostics, Pitam Pura, New Delhi, India

Correspondence Address:
Dr. Madhuri Shimpi Mahajan
Department of Nuclear Medicine, Saral Advanced Diagnostics, E-1073, Saraswati Vihar, Pitam Pura, New Delhi - 110 034
India

Tc-99m methylene diphosphonate (MDP) bone scintigraphy has long been used for the evaluation of benign as well as malignant skeletal conditions. However, non-osseous tracer uptake on a bone scan is an unusual finding. On one hand, there is a need for awareness of the pathophysiologic basis underlying such uptake, as it may be of critical clinical relevance in the evaluation of the patient. On the other hand, some alterations in biodistribution may be of little clinical significance, but have deleterious consequences on the quality of the bone study. Recognition of these abnormalities will reduce errors and provide important clinical information. We described a case of 57-year-old male patient with history of carcinoma base of tongue, where a 99mTc-MDP bone Scintigraphy was performed for metastasis survey. It revealed avascular necrosis of head of right femur. In addition incidentally demonstrated diffuse increased pathologic uptake of Tc-99m-MDP in the liver and multiple foci in bilateral lungs. This article reviews several possible reasons for such diffuse hepatic uptake. In the present case diffuse hepatic necrosis secondary to respiratory failure due to bilateral miliary pulmonary metastasis is considered to be the cause of the diffuse liver uptake of 99mTc-MDP.


How to cite this article:
Mahajan MS, Digamber NS, Sharma R. Technetium-99m-methylene Diphosphonate Uptake in Hepatic Necrosis Secondary to Respiratory Failure.World J Nucl Med 2013;12:116-119


How to cite this URL:
Mahajan MS, Digamber NS, Sharma R. Technetium-99m-methylene Diphosphonate Uptake in Hepatic Necrosis Secondary to Respiratory Failure. World J Nucl Med [serial online] 2013 [cited 2022 Aug 11 ];12:116-119
Available from: http://www.wjnm.org/article.asp?issn=1450-1147;year=2013;volume=12;issue=3;spage=116;epage=119;aulast=Mahajan;type=0