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18FDG PET-CT in sporadic Creutzfeldt-Jakob disease, correlated with MRI and histology


1 Department of Radiology, Oxford, United Kingdom
2 Department of Neuropathology, Oxford, United Kingdom
3 Department of Psychiatry, University of Oxford, Oxford, United Kingdom

Correspondence Address:
Nicholas C. D. Morley,
Velindre Cancer Centre (X.Ray Department), Cardiff CF14 2TL
United Kingdom
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/wjnm.wjnm_5_21

We present a case of sporadic Creutzfeldt-Jakob disease with profoundly abnormal 18fluoro-deoxy-glucose positron emission tomography with computed tomography (FDG PET-CT) at an early stage, and correlate this with the clear findings at magnetic resonance imaging and also postmortem histology. Prion diseases are rare but important causes of cognitive impairment. The role of FDG PET-CT is discussed, along with other investigations such as electroencephalography and cerebro-spinal fluid analyses.


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    -  Morley NC
    -  Hofer M
    -  Wilkinson P
    -  Bradley KM
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