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The role of nuclear medicine in a case of Rendu–Osler–Weber disease with pulmonary involvement


1 Densitometry and Nuclear Medicine Physician, Head of the Nuclear Medicine Service of Hospital das Clínicas-Federal University of Minas Gerais Clinics (HC-UFMG), Belo Horizonte, Minas Gerais, Brazill
2 Resident doctor, Head of the Nuclear Medicine Service of Hospital das Clínicas-Federal University of Minas Gerais Clinics (HC-UFMG), Belo Horizonte, Minas Gerais, Brazill
3 Radiopharmacist, Head of the Nuclear Medicine Service of Hospital das Clínicas-Federal University of Minas Gerais Clinics (HC-UFMG), Belo Horizonte, Minas Gerais, Brazill
4 Head of the Nuclear Medicine Service of Hospital das Clínicas-Federal University of Minas Gerais Clinics (HC-UFMG); Assistant Professor at the Department of Anatomy and Image, Faculty of Medicine, UFMG. Belo Horizonte, Minas Gerais, Brazill

Correspondence Address:
Carlyle Marques Barral,
Rua Professor Morais, 476/901, Savassi, Belo Horizonte, Minas Gerais
Brazill
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/wjnm.wjnm_48_21

Rendu–Osler–Weber syndrome or hereditary hemorrhagic telangiectasia (HHT) is a rare systemic disease. Its primary pathogenic expression is multiple arteriovenous malformations (AVM) and severe hypoxia. A case of suspected pulmonary embolism in a 49-year-old male with intestinal, cardiac, and pulmonary HHT affection is reported. Pulmonary AVM could create an apparent mismatch perfusion defect evident upon ventilation and perfusion scan (V/Q scan), leading to misinterpretation. It reinforces the importance between clinics, anatomy, and functional evaluation. Care must be taken when interpreting V/Q scan and the reporting physician must be alert to the possible sources of errors.


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    -  Barral CM
    -  Nunes IC
    -  Nunes SS
    -  Sanches SM
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