|Year : 2020 | Volume
| Issue : 3 | Page : 322-323
Isolated aplasia of submandibular salivary gland and contralateral prominence of submandibular and sublingual salivary glands incidentally found on68Ga-prostate-specific membrane antigen positron emission tomography–computed tomography
Abbas Yousefi-Koma1, Reyhane Ahmadi2, Saba Karami Gorzi3, Yaser Shiravand2, Mohsen Qutbi2
1 Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Nuclear Medicine, School of Medicine, Taleghani Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
|Date of Submission||10-Feb-2020|
|Date of Decision||01-May-2020|
|Date of Acceptance||21-May-2020|
|Date of Web Publication||22-Jul-2020|
Dr. Mohsen Qutbi
Department of Nuclear Medicine, Taleghani Hospital, Yaman St., Velenjak, Tehran 1985711151
| Abstract|| |
Prostate-specific membrane antigen (PSMA)-targeted imaging is now an effective tool for the evaluation of prostate cancer patients. Although salivary glands take up68Ga-PSMA avidly, pathologies of these glands may be readily noticeable. Herein, we present a case of prostate cancer referred for68Ga-PSMA positron emission tomography–computed tomography in whom an isolated aplasia of the submandibular salivary gland was incidentally found.
Keywords: 68Ga-prostate-specific membrane antigen positron emission tomography–computed tomography, isolated aplasia, submandibular salivary gland
|How to cite this article:|
Yousefi-Koma A, Ahmadi R, Gorzi SK, Shiravand Y, Qutbi M. Isolated aplasia of submandibular salivary gland and contralateral prominence of submandibular and sublingual salivary glands incidentally found on68Ga-prostate-specific membrane antigen positron emission tomography–computed tomography. World J Nucl Med 2020;19:322-3
|How to cite this URL:|
Yousefi-Koma A, Ahmadi R, Gorzi SK, Shiravand Y, Qutbi M. Isolated aplasia of submandibular salivary gland and contralateral prominence of submandibular and sublingual salivary glands incidentally found on68Ga-prostate-specific membrane antigen positron emission tomography–computed tomography. World J Nucl Med [serial online] 2020 [cited 2021 Sep 16];19:322-3. Available from: http://www.wjnm.org/text.asp?2020/19/3/322/290369
| Introduction|| |
We present a case of prostate cancer referred for68 Ga-prostate-specific membrane antigen (PSMA) positron emission tomography–computed tomography (PET-CT) in whom an isolated aplasia of the submandibular salivary gland was incidentally found.
| Case Summary|| |
A 68-year-old patient with prior adenocarcinoma of the prostate and then radical prostatectomy was referred for metastatic evaluation following a rise in the serum prostate-specific antigen level. After obtaining informed consent, the patient underwent a68 Ga-PSMA PET-CT scan 60 min after intravenous administration of 208 MBq of68 Ga-PSMA from the vertex to the upper thigh [Figure 1]a, on which, in addition to residual or recurrent disease in the surgical bed of prostatectomy, the submandibular salivary gland was absent on the right side, and in contrast, the contralateral one seemed prominent. The sublingual glands were also asymmetric [Figure 1]b, [Figure 1]c, [Figure 1]d. PSMA has become a favorable molecular target for imaging of the prostate cancer tissues, and to date, PSMA-based PET scanning has been successfully incorporated into the clinical practice. Despite its distinct advantages in the diagnosis and therapy of malignant prostate tissues, the use of such target for imaging has been challenged, to some extent, as a result of a diverse range of false-positive and incidental prostate-unrelated findings.,, Salivary glands normally demonstrate intense uptake on68 Ga-PSMA PET-CT. Either decrease or absence of uptake, particularly when unilateral, may be a clinically significant finding and deserves attention. Congenital absence of salivary glands is rare and mostly multiple glands are involved. Unilateral “isolated” aplasia of submandibular salivary gland is an exceptionally rare finding. It may be associated with other anomalies such as hemifacial microsomia and mandibulofacial dysostosis.,,, The biologic mechanism is not clearly known, but may result from defect in fibroblast growth factor signaling pathways that prevents development of salivary gland tissue during embryogenesis., On the other hand, the contralateral submandibular salivary gland, as in our patient, or sometimes ipsilateral or contralateral sublingual salivary glands may show more prominence, possibly as a compensatory hypertrophy against xerostomia., This issue, in turn, poses interpretive challenges because of pathology of the gland itself or obscuring adjacent (e.g., mandibular) PSMA-avid lesions.
|Figure 1: Anterior maximum intensity projection image (a) of68Ga-prostate-specific membrane antigen positron emission tomography–computed tomography shows absent submandibular salivary gland on the right side as well as prominence of the contralateral one. The absent gland is better depicted on68Ga-prostate-specific membrane antigen positron emission tomography (b), computed tomography (c), and fused positron emission tomography–computed tomography image (d)|
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| Conclusion|| |
68 Ga-PSMA PET-CT imaging as a promising modality for the evaluation of patients with prostate cancer is being incorporated into clinical practice. Familiarity with pitfalls, limitations, and also varieties of incidental findings may be of importance for clinicians.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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