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Year : 2020  |  Volume : 19  |  Issue : 2  |  Page : 159-161

Neurolymphomatosis – Rare presentation in non-Hodgkin's lymphoma: The role of18F-fluorodeoxyglucose positron-emission tomography and computerized tomography imaging

1 Department of Radiology, The Aga Khan University Hospital, Karachi, Pakistan
2 Department of Medicine, Civil Hospital Karachi, Karachi, Pakistan
3 Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan

Correspondence Address:
Dr. Maseeh Uz Zaman
Department of Radiology, The Aga Khan University Hospital, Karachi
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DOI: 10.4103/wjnm.WJNM_22_19

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Neurolymphomatosis (NLS) is infiltration of lymphoma cells into the peripheral or cranial nervous system and is a rare manifestation of non-Hodgkin lymphoma (NHL). Nerve biopsy is considered as the gold standard for diagnosis but not a preferred choice, and magnetic resonance imaging has lower reported sensitivity.18F-Fluorodeoxyglucose (18FDG) positron-emission tomography and computerized tomography (PET/CT) has a higher sensitivity for diagnosing and assessing the neurological and nonneurological metabolic tumor volume and response evaluation to therapy. We present the case of a lady, known to have NHL in remission. She presented with a short history of severe pain and weakness of the right lower limb. Baseline and interim18FDG PET/CT played a crucial role in diagnosing and assessing the extent of NLS and nonneurological disease burden and also in evaluation of response to treatment.

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