|Year : 2020 | Volume
| Issue : 2 | Page : 149-151
An unusual case of hyperparathyroidism, presenting as multiple skeletal lesions
Nitin Gupta1, Ankur Pruthi2, Ritu Verma1, Anisha Manocha3
1 Department of Nuclear Medicine and PET/CT, Mahajan Imaging Centre, Sir Ganga Ram Hospital, New Delhi, India
2 Department of Nuclear Medicine and PET/CT, Manipal Hospital, New Delhi, India
3 Department of Pathology, Sir Ganga Ram Hospital, New Delhi, India
|Date of Submission||26-Aug-2019|
|Date of Acceptance||15-Oct-2019|
|Date of Web Publication||17-Jan-2020|
Dr. Nitin Gupta
Department of Nuclear Medicine and PET/CT, Mahajan Imaging Centre, Sir Ganga Ram Hospital, New Delhi - 110 060
| Abstract|| |
We report the case of a 43-year-old male patient, who presented with severe osteoporosis and pain at multiple sites and a chest X-ray suggestive of few cystic lesions in bilateral ribs. Subsequently, the patient was referred for bone scan, in view of the suspicion of polyostotic fibrous dysplasia or neoplastic lesions. Bone scan showed homogenously increased tracer uptake in the axial and appendicular skeletal system, suggestive of metabolic superscan. Computed tomography neck localized right inferior parathyroid adenoma and expansile lytic skeletal lesions suggestive of brown tumors were also seen. This case highlights the importance of bone scan, helping in the differential diagnosis of multiple skeletal lesions.
Keywords: Brown tumors, hyperparathyroidism, Methylene diphosphonate (MDP) bone scan, skeletal lesions
|How to cite this article:|
Gupta N, Pruthi A, Verma R, Manocha A. An unusual case of hyperparathyroidism, presenting as multiple skeletal lesions. World J Nucl Med 2020;19:149-51
|How to cite this URL:|
Gupta N, Pruthi A, Verma R, Manocha A. An unusual case of hyperparathyroidism, presenting as multiple skeletal lesions. World J Nucl Med [serial online] 2020 [cited 2020 Nov 26];19:149-51. Available from: http://www.wjnm.org/text.asp?2020/19/2/149/275849
| Introduction|| |
Majority of the hyperparathyroidism cases are diagnosed when a routine assay shows hypercalcemia. Symptoms include recurrent renal stones, asthenia, neuromuscular or psychiatric disorders, gastrointestinal manifestations, or osteoporosis. Brown tumors are rare nonneoplastic lesions that arise in the setting of hyperparathyroidism. They can arise as solitary or multiple lesions of any bone, more common in the extremities, clavicle, ribs, and pelvis. We report an unusual case in which a patient presented with multiple skeletal lesions and bone scan and further investigations helped in the diagnosis.
| Case Report|| |
A 43-year-old male patient who presented with pain at multiple sites was referred for whole-body bone scan with suspicion of polyostotic fibrous dysplasia, other differentials being multiple myeloma or metastatic lesions. Whole-body bone scan, anterior and posterior views [Figure 1]a and [Figure 1]b, was suggestive of homogenously increased tracer uptake in the axial and appendicular skeleton system with faint visualization of the kidneys, likely suggestive of metabolic superscan. Since chest X-ray revealed cystic lesions, and relevant biochemical parameters were raised serum calcium (12.8 mg/dl, range: 8.6–10.2 mg/dl), raised alkaline phosphatase (592 IU/L, range: 20–140 IU/L), and low inorganic phosphorus (1.8 mg/dl, range: 2.5–4.5 mg/dl), suspicion of parathyroid adenoma was raised. Noncontrast computed tomography neck, transaxial and coronal sections [Figure 1]c and [Figure 1]e localized large hypodense nodular lesion in relation to the inferior pole of the right lobe of the thyroid gland, and bone window transaxial and coronal sections [Figure 1]d and [Figure 1]f revealed expansile lytic lesions involving the ribs and scapula. On further blood test, serum parathyroid hormone was ~1700 pg/ml (range: 10–65 pg/ml), correlating with other findings and confirming diagnosis of primary hyperparathyroidism with multiple skeletal lesions. Subsequently, the lesion was excised, and histopathology report [Figure 2] confirmed parathyroid adenoma.
|Figure 1: Whole-body bone scan, anterior and posterior views (a and b), suggestive of homogenously increased tracer uptake in the axial and appendicular skeleton system with faint visualization of the kidneys. Noncontrast computed tomography neck, transaxial and coronal sections (c and e), localized large hypodense nodular lesion in relation to the inferior pole of the right lobe of the thyroid gland, and bone window transaxial and coronal sections (d and f) revealed expansile lytic lesions involving the ribs and scapula|
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|Figure 2: Histopathology images of the specimen. Section (a) shows an encapsulated tumor composed of cells arranged in nests separated by thin-walled vasculature (H and E, ×4). Section (b) shows an encapsulated tumor composed of cells arranged in nests separated by thin-walled vasculature (H and E, ×10). The adenoma cells show (c) monomorphic nuclei with stippled chromatin, inconspicuous nucleoli, and moderate amount of clear-to-pale eosinophilic cytoplasm (H and E, ×20)|
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| Discussion|| |
Primary hyperparathyroidism is a disease characterized by excessive secretion of parathormone. Multiple skeletal lesions (brown tumors) represent a rare clinical manifestation of prolonged hyperparathyroidism and reported in approximately 3% of patients with primary hyperparathyroidism. Differential diagnosis of multiple bony lesions include metastatic lesions, bone cysts, osteosarcoma, and giant-cell tumor. There are various reports of brown tumors imitating skeletal metastases. Although homogeneously increased tracer uptake in bone scan, with greater uptake in the appendicular skeleton compared to axial skeleton and faint visualization of kidneys, raises suspicion of metabolic superscan and in presence of raised calcium, primary hyperparathyroidism appears more likely with less chances of malignancy, but few cases of secondary hyperparathyroidism have been reported in prostate cancer patients with bone metastases. However, there was no known history of carcinoma prostate in our patient, and serum prostate-specific antigen levels were also normal (0.5 ng/ml, range: 0.2–4.0 ng/ml); later, histopathology report of parathyroid lesion confirmed parathyroid adenoma in the patient. Few cases have been reported in literature, where multiple skeletal lesions were later diagnosed due to hyperparathyroidism.,,,, The classical radiographic features of skeletal lesions (brown tumors) in hyperparathyroidism are osteopenia and diffuse subperiosteal bone resorption. Thus, in case of hypercalcemia and multiple lytic lesions, primary hyperparathyroidism should always be kept in differential diagnosis, and further biochemical evaluation and bone scan can help in management.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
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Conflicts of interest
There are no conflicts of interest.
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