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Year : 2020  |  Volume : 19  |  Issue : 1  |  Page : 61-64

Failure of iodine uptake in microscopic pulmonary metastases after recombinant human thyroid-stimulating hormone stimulation

1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
2 Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Francisco, CA, USA
3 Department of Endocrinology, Southern California Permanente Medical Group, Fontana, CA, USA

Correspondence Address:
Dr. Courtney Lawhn-Heath
Department of Radiology and Biomedical Imaging, University of California, 505 Parnassus Avenue, M-391, San Francisco, CA
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/wjnm.WJNM_29_19

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Elevated thyroid stimulating hormone (TSH) is required when preparing for radioactive iodine therapy in patients with differentiated thyroid cancer. Recombinant human TSH (rhTSH: Thyrogen; Genzyme Corporation, Cambridge, MA) avoids hypothyroidism and has been commonly used in place of thyroid hormone withdrawal (THW) in this process. We describe a 31-year-old woman with sclerosing variant of papillary thyroid cancer with multiple lymph node metastases and elevated postoperative thyroglobulin suggesting the presence of distant metastases, who was found to have miliary pulmonary metastases on the posttherapy I-131 scan after THW, but not visible on the post therapy scan after rhTSH preparation.

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