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Year : 2018  |  Volume : 17  |  Issue : 2  |  Page : 102-105

A case of well-differentiated hepatocellular carcinoma identified on gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography

1 Department of Nuclear Medicine and Molecular Imaging, General Hospital, Singapore
2 Department of Pathology, General Hospital, Singapore
3 Department of Surgical Oncology, National Cancer Centre , General Hospital, Singapore

Correspondence Address:
Hian Liang Huang
Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, 1 Outram Road
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DOI: 10.4103/wjnm.WJNM_11_17

PMID: 29719484

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Prostate-specific membrane antigen (PSMA) is a glycosylated type-II transmembrane protein highly expressed in certain tumor cells. To the best of our knowledge, this is the first case reported of an isolated well-differentiated hepatocellular carcinoma (HCC) strongly suspected on gallium-68 (68Ga)-PSMA positron emission tomography/computed tomography (PET/CT), which was not well characterized both on magnetic resonance imaging (MRI) liver with Primovist as well as fluorine-18 (18F)-choline PET/CT. Our patient had previous prostate cancer and previously was imaged using 18F-choline PET/CT. The last scan showed an indeterminate segment VII hypodensity which was not significantly choline-avid. The lesion was initially stable on serial MRI scans but then showed growth from 1.0 to 1.5 cm. 68Ga-PSMA PET/CT was performed. The lesion was intensely tracer-avid. This was surgically excised and histology confirmed the presence of well-differentiated HCC. Well-differentiated HCC can be optimally imaged using 68Ga-PSMA PET/CT and further prospective studies are needed to look into the potential of this imaging modality.

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