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Year : 2017  |  Volume : 16  |  Issue : 4  |  Page : 320-323

Regional liver disorder with differences in the accumulation of 99mTc-phytate and 99mTc-galactosyl human serum albumin

Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan

Correspondence Address:
Kohei Kotani
Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585
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DOI: 10.4103/1450-1147.215493

PMID: 29033683

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We report a 56-year-old woman with regional liver disorder due to acute hepatitis. Computed tomographic images showed low signal density at a plain phase and prolonged contrast effect at a late phase in the left hepatic lobe, in which an accumulation of 99mTc-phytate increased, whereas that of 99mTc-galactosyl human serum albumin (GSA) decreased. Meanwhile, in the right lobe, an accumulation of 99mTc-GSA showed more increased than that of 99mTc-phytate. Liver biopsy showed massive hepatocyte necrosis and interface hepatitis in the left lobe, and moderate hepatitis in the right lobe. Differences in the accumulation between these scintigrams were helpful for understanding rapid necrosis in the left lobe, resulting in a compensatory enlargement of the right lobe. Clinicians should be aware that some cases of acute hepatitis cause regional liver disorder although most cases show homogeneous inflammation.

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