Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
  Home Print this page Email this page Small font sizeDefault font sizeIncrease font size Users Online: 570  
Year : 2017  |  Volume : 16  |  Issue : 1  |  Page : 3-7

68 Ga-prostate-specific membrane antigen positron emission tomography/computed tomography for prostate cancer imaging: A narrative literature review

1 Lenitudes Medical Center and Research, Sta. Maria Feira; HPP - Nuclear Medicine, Porto, Portugal
2 Lenitudes Medical Center and Research, Sta. Maria Feira, Porto, Portugal
3 Lenitudes Medical Center and Research, Sta. Maria Feira; HPP - Nuclear Medicine, Porto; Health School of University of Aveiro, Aveiro, Portugal
4 Lenitudes Medical Center and Research, Sta. Maria Feira, Porto; Center of Study and Research in Health of University of Coimbra, Coimbra, Portugal

Correspondence Address:
Catarina Gomes
Lenitudes Medical Center and Research, Rua Prof. Doutor Serafim Pinto Guimar„es, No. 222, 4520-103 Espargo, Sta. Maria da Feira
Login to access the Email id

DOI: 10.4103/1450-1147.198237

PMID: 28217012

Rights and Permissions

The 68 Ga-prostate-specific membrane antigen ( 68 Ga-PSMA) has been recently developed to be used, as a ligand, in positron emission tomography/computed tomography (PET/CT) prostate cancer imaging, to detect prostate disease. The main objective of this review was to collect data and findings from other studies and articles to assess, theoretically, if 68 GA-PSMA PET/CT is a more appropriate prostate cancer diagnostic technique in comparison with others available such as CT, 18 F-fluoro-2-deoxyglucose PET/CT, or 18 F-fluoromethylcholine ( 18 F-choline) PET/CT. For that purpose, PubMed, the online scientific articles' database, was consulted where the keywords "PSMA" and "PET" were used to find relevant articles. The clinicaltrials.gov, clinical trials' database, was also consulted where the keywords " 68 Ga-PSMA" and "prostate" were used to search clinical trials. Based on the reviewed scientific literature, several studies were conducted to assess and compare the 68 Ga-PSMA PET/CT detection rate in prostate cancer with other available techniques. One of those studies, conducted by Giesel et al., concluded, within study sample, that 75% of patients with lymph nodes detected by 68 Ga-PSMA PET/CT would have not been identified using other conventional morphological criteria based techniques. In Eiber et al.'s study, 68 Ga-PSMA PET detected prostatic disease findings in 67% of patients with prostate-specific antigen levels <1 ng/mL, when compared with choline-based PET that presented detection rates between 19% and 36%. In Bluemel et al.'s study, 68 Ga-PSMA identified positive prostatic disease in 43.8% of the patients with negative findings in F-choline PET/CT. Findings from this review demonstrate that 68 Ga-PSMA PET/C is more effective in detecting metastases, lymph nodes, and recurrent prostate cancer when compared to 18 F-choline-based PET/CT and CT. 68 Ga-PSMA PET/CT presents also more imaging contrast and can be more cost-effective. 68 Ga-PSMA has already been subjected to first-in-human trials, and it is now being tested in Phase II and III trials.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded664    
    Comments [Add]    
    Cited by others 12    

Recommend this journal