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Year : 2016  |  Volume : 15  |  Issue : 1  |  Page : 50-52

The complimentary role of Methoxy-Isobutyl-Isonitrile and hand-held gamma probe in adamantinoma

1 Department of Nuclear Medicine, Umhlanga Molecular Imaging and Therapy, Centre of Excellence, Umhlanga, South Africa
2 Department of Medical Imaging and Clinical Oncology, Stellenbosch University, and Tygerberg Hospital, South Africa

Correspondence Address:
Masha Maharaj
Department of Nuclear Medicine, Umhlanga Molecular Imaging and Therapy, Centre of Excellence, Umhlanga, 4319
South Africa
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DOI: 10.4103/1450-1147.167600

PMID: 26912979

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Adamantinoma is a rare locally aggressive osteolytic tumor that is found 90% of the time in the diaphysis of the tibia with the remaining lesions found in the fibula and long tubular bones. A case of adamantinoma of the tibia is presented. The added value of nuclear medicine investigations in the workup of this patient is described. A three-phase whole body 99mTc-methylene diphosphonate bone and a whole body 99mTc-methoxy-isobutyl-isonitrile scans were complimentary in the demarcation of viable bone tumor and the assessment of the remainder of the bone and soft tissue to exclude other sites. Intra-operative assistance with a hand-held gamma probe, guided the biopsy of the most metabolically active tumor tissue. Histology revealed a biphasic tumor composed of epithelial and fibrous components, in keeping with an adamantinoma.

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