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CASE REPORT
Year : 2015  |  Volume : 14  |  Issue : 3  |  Page : 216-218

Radiosynovectomy of Proximal Interphalangeal Joint Synovitis in Rheumatoid Arthritis Treated with Rhenium-188 Labeled Tin-colloid and Imaging with Single-photon Emission Computerized Tomography/Computed Tomography: A First Case Report

Koramadai Karuppusamy Kamaleshwaran1, Venkataraman Rajamani2, Boopathi Krishnan3, Madhav Mallia4, Radhakrishnan Kalarikal1, Vyshakh Mohanan1, Ajit Sugunan Shinto1
1 Department of Nuclear Medicine and PET/CT, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India
2 Department of Rheumatology, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India
3 Department of Orthopedics, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India
4 Radiopharmaceuticals Chemistry Section, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Koramadai Karuppusamy Kamaleshwaran
Department of Nuclear Medicine, PET/CT and Radionuclide Therapy, Comprehensive Cancer Care Center, Kovai Medical Center and Hospital Limited, Coimbatore - 641 014, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1450-1147.161730

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Rheumatoid arthritis (RA) is a chronic disease that is mainly characterized by the asymmetric erosive synovitis, particularly affecting peripheral joints. Radiation synovectomy or radiosynovectomy (RSV), also known as radiosynoviorthesis was first described in 1950's as an adjuvant treatment for RA. RSV is based on the irradiation of the joint synovium by the intra-articular administration of various β-emitting radiopharmaceuticals. As a generator-produced β-emitting radionuclide, the importance of rhenium-188 (Re-188) for radionuclide therapy is increasing rapidly. There are previous reports which used Re-188 tin colloid in knee joint synovitis, but use of Re-188 tin colloid in small joint is not yet reported. We describe the use of Re-188 tin colloid in a 45-year-old female who presented with right 4 th proximal interphalangeal joint synovitis due to rheumatoid arthritis.


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