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  Indian J Med Microbiol
 

Figure 3: An 86-year-old male (patient 8), known case of chronic kidney disease, presenting with headache and limb weakness, underwent a MRI at a regional center; axial images (a) showed an ill-defined T1 hypointense, T2 iso-to-hypointense corpus callosal lesion infiltrating the ventricles and right thalamus, no contrast could be administered, there was facilitated diffusion on diffusion-weighted imaging and ADC map; hyperperfusion on MR perfusion images differentials of PCNSL and high-grade glioma were given. FET-PET showed tumor-to-contralateral white mater (T/Wm) ratio of 2.6 on both 5 (c) and 20 (d) minute images. 5-min image is an index of vascularity, however, since maximum uptake occurs till 20 min, increased 20-min uptake in the hyperperfused lesions seen at 5 min is suggestive of high-grade glioma. Histopathology revealed Grade IV gliomas

Figure 3: An 86-year-old male (patient 8), known case of chronic kidney disease, presenting with headache and limb weakness, underwent a MRI at a regional center; axial images (a) showed an ill-defined T1 hypointense, T2 iso-to-hypointense corpus callosal lesion infiltrating the ventricles and right thalamus, no contrast could be administered, there was facilitated diffusion on diffusion-weighted imaging and ADC map; hyperperfusion on MR perfusion images differentials of PCNSL and high-grade glioma were given. FET-PET showed tumor-to-contralateral white mater (T/Wm) ratio of 2.6 on both 5 (c) and 20 (d) minute images. 5-min image is an index of vascularity, however, since maximum uptake occurs till 20 min, increased 20-min uptake in the hyperperfused lesions seen at 5 min is suggestive of high-grade glioma. Histopathology revealed Grade IV gliomas