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2012| September-December | Volume 11 | Issue 3
Online since
November 10, 2012
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EDITORIALS
When was the Last Time You did Something for the First Time?
Ajit Kumar Padhy
September-December 2012, 11(3):99-100
DOI
:10.4103/1450-1147.103404
PMID
:23372444
[FULL TEXT]
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[PubMed]
2,184
10,928
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ABSTRACTS
ICRT-Abstracts of Poster Presentations
September-December 2012, 11(3):160-200
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4,619
352
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ICRT-Speakers' Abstracts
September-December 2012, 11(3):121-153
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3,565
265
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EDITORIALS
Nuclear Medicine in Finland
Kalevi Kairemo
September-December 2012, 11(3):101-102
DOI
:10.4103/1450-1147.103406
PMID
:23372445
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
1,876
1,877
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Global WARMTH for Patients with Cancer
J Harvey Turner
September-December 2012, 11(3):103-104
DOI
:10.4103/1450-1147.103407
PMID
:23372446
[FULL TEXT]
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[EPub]
[PubMed]
1,609
1,767
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ORIGINAL ARTICLES
Standard Operating Procedure for In-house Preparation of
131
I-rituximab for Radioimmunotherapy of Non-Hodgkin's Lymphoma
Matthew D Pickford, J Harvey Turner
September-December 2012, 11(3):105-109
DOI
:10.4103/1450-1147.103408
PMID
:23372447
A Standard Operating Procedure (SOP) has been formulated for in-house preparation, quality control, dispensing and administration of
131
I-rituximab appropriate for the safe, effective, radioimmunotherapy of non-Hodgkin lymphoma. A decade of experience of semi-automated radioiodination of rituximab in our hospital radiopharmaceutical laboratory was analysed. The methodology was then refined for safe, practical, affordable application to radioimmunotherapy of lymphoma in departments of nuclear medicine in developing countries. This SOP has the potential to be incorporated into good laboratory practice conditions appropriate for local regulatory agency requirements.
[ABSTRACT]
[FULL TEXT]
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[CITATIONS]
[PubMed]
2,859
515
2
Standard Operating Procedure for Prospective Individualised Dosimetry for
[131]
I-rituximab Radioimmunotherapy of Non-Hodgkin's Lymphoma
Phillipe J Calais, J Harvey Turner
September-December 2012, 11(3):110-116
DOI
:10.4103/1450-1147.103409
PMID
:23372448
Radioimmunotherapy (RIT) is an attractive therapy for non-Hodgkin's lymphoma (NHL) as it allows targeted tumor irradiation which provides a cytotoxic effect significantly greater than that of the immune-mediated effects of a non-radioactive, or 'cold', antibody alone. Anti-CD20 antibodies such as rituximab are ideal for RIT, as not only is it easily iodinated, but the CD20 antigen is found on more than 95% of B-cell NHL. A standard operating procedure (SOP) has been formulated for personalized prospective dosimetry for safe, effective outpatient
131
I-rituximab RIT of NHL. Over five years, experience of treatment of outpatients with
131
I-rituximab was analyzed with respect to critical organ radiation dose in patients and radiation exposure of their carers. This radiation safety methodology has been refined; and offers the potential for safe, practical application to outpatient
131
I-rituximab RIT of lymphoma in general and in developing countries in particular. Given endorsement and sanction of this SOP by local regulatory authorities the personalized dosimetry paradigm will facilitate incorporation of RIT into the routine clinical practice of therapeutic nuclear oncology worldwide.
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2,493
512
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ABSTRACTS
ICRT-Abstracts of Oral Presentations
September-December 2012, 11(3):154-159
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2,784
200
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Warmth 7
th
International Conference on Radiopharmaceutical Therapy (Icrt 2012) Levi, Finland
September-December 2012, 11(3):117-117
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1,153
185
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Pre-conference Symposium on Nuclear Cardiology
September-December 2012, 11(3):118-121
[FULL TEXT]
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[EPub]
1,057
150
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