World Journal of Nuclear Medicine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 18  |  Issue : 4  |  Page : 361--365

Using positron-emission tomography–computed tomography for predicting radiotherapy-induced tumor regression in carcinoma esophagus in an Indian population


Sankalp Singh1, Niharika Bisht2, Arti Sarin2, A. V. S. Anil Kumar3, Samir Gupta2, Amul Kapoor2, Prabha Shankar Mishra4 
1 Department of Radiation Oncology, Command Hospital (CC), Lucknow, Uttar Pradesh, India
2 Department of Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, India
3 Department of Nuclear Medicine, Command Hospital (SC), Pune, Maharashtra, India
4 Department of Pathology, Command Hospital (SC), Pune, Maharashtra, India

Correspondence Address:
Dr. Niharika Bisht
Command Hospital(SC), Pune-411040, Maharashtra
India

Carcinoma esophagus is a common malignancy of the Indian subcontinent. The role of positron-emission tomography–computed tomography (PET-CT) in the assessment of response to radiotherapy has been widely studied and accepted. However, its precise use as a predictive tool for actual histopathological response to radiotherapy needs further evaluation, especially in an Indian population. The aim of this study was to identify a quantum of metabolic response on PET-CT that can also predict for a good pathological response. Forty-four patients of carcinoma esophagus treated with neoadjuvant chemoradiotherapy followed by surgery were included in the study. All patients underwent a PET-CT before starting treatment as well as at 4–6 weeks after completion of radiotherapy. The percentage change in pre and posttreatment maximum standardized uptake value (SUVmax) value (ΔSUV%) of the primary tumor was correlated against histopathological tumor regression grade (TRG) as per the Mandard's system. Seventy-five percent of the patients with a significant metabolic response, i.e., a ΔSUV% of 60% or more, also had a good pathological response to treatment. Thus, by considering a ΔSUV% of 60%, we could predict for a good pathological response (TRG of 1 or 2) to chemoradiotherapy in our patient set with a sensitivity of 95.45% and a specificity of 72.72%.


How to cite this article:
Singh S, Bisht N, Sarin A, Kumar AA, Gupta S, Kapoor A, Mishra PS. Using positron-emission tomography–computed tomography for predicting radiotherapy-induced tumor regression in carcinoma esophagus in an Indian population.World J Nucl Med 2019;18:361-365


How to cite this URL:
Singh S, Bisht N, Sarin A, Kumar AA, Gupta S, Kapoor A, Mishra PS. Using positron-emission tomography–computed tomography for predicting radiotherapy-induced tumor regression in carcinoma esophagus in an Indian population. World J Nucl Med [serial online] 2019 [cited 2020 Jan 27 ];18:361-365
Available from: http://www.wjnm.org/article.asp?issn=1450-1147;year=2019;volume=18;issue=4;spage=361;epage=365;aulast=Singh;type=0