World Journal of Nuclear Medicine

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 11  |  Issue : 1  |  Page : 3--6

Pituitary Incidentalomas Detected with Technetium-99m MIBI in Patients with Suspected Parathyroid Adenoma: Preliminary Results


Ekaterina Tiktinsky1, Tifha Horne1, Michael Friger2, Svetlana Agranovich1, Sophie Lantsberg1 
1 Department of Nuclear Medicine, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
2 Department of Epidemiology and Health Services Evaluation, Ben Gurion University of the Negev, Beer Sheva, Israel

Correspondence Address:
Ekaterina Tiktinsky
P.O. Box 151, Beer Sheva 84100
Israel

Tc-99m MIBI (MIBI) is a cationic lipophilic agent, which has traditionally been used for myocardial perfusion scintigraphy, detection and monitoring of different benign and malignant tumors. The objective of this study was to evaluate the frequency of pituitary incidentalomas detected on MIBI scans performed on patients with suspected parathyroid adenomas and to provide semiquantitative analysis of tracer uptake in the pituitary region. Tomographic images of MIBI scans on 56 patients with suspected parathyroid adenomas (2006-2007) were analyzed retrospectively. Semiquantitative analysis of abnormal uptake was performed by drawing identical regions of interest (ROI) over the pituitary area and the normal brain on one transverse section that demonstrates the lesion most clearly. Pituitary uptake to normal brain uptake ratio was calculated in all cases. We found statistically significant differences of MIBI uptake in patients with pituitary adenomas, mean ratio: 29.78±12.17 (median 29.77, and range 19-41), compared with patients with no pathologic changes in this region, mean ratio was 5.88±1.82 (median was 5.95 and range 2.0- 9.2). As the groups are too small for statistical analysis, these results need to be confirmed in a larger cohort and should include more detailed biochemical correlation. MIBI parathyroid scintigraphy should be taken into account as a potential source of identifying pituitary incidentalomas. Clinical significance of these findings needs further evaluation.


How to cite this article:
Tiktinsky E, Horne T, Friger M, Agranovich S, Lantsberg S. Pituitary Incidentalomas Detected with Technetium-99m MIBI in Patients with Suspected Parathyroid Adenoma: Preliminary Results.World J Nucl Med 2012;11:3-6


How to cite this URL:
Tiktinsky E, Horne T, Friger M, Agranovich S, Lantsberg S. Pituitary Incidentalomas Detected with Technetium-99m MIBI in Patients with Suspected Parathyroid Adenoma: Preliminary Results. World J Nucl Med [serial online] 2012 [cited 2020 Jul 16 ];11:3-6
Available from: http://www.wjnm.org/article.asp?issn=1450-1147;year=2012;volume=11;issue=1;spage=3;epage=6;aulast=Tiktinsky;type=0