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Neurolymphomatosis–Rare presentation in non-Hodgkin's lymphoma: The role of 18F-fluorodeoxyglucose positron-emission tomography and computerized tomography imaging


1 Departments of Radiology, The Aga Khan University Hospital, Karachi, Pakistan
2 Department of Medicine, Civil Hospital Karachi, Karachi, Pakistan
3 Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan

Correspondence Address:
Maseeh Uz Zaman,
Department of Radiology, The Aga Khan University Hospital, Karachi
Pakistan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/wjnm.WJNM_22_19

Neurolymphomatosis(NLS) is infiltration of lymphoma cells into the peripheral or cranial nervous system and is a rare manifestation of non-Hodgkin lymphoma(NHL). Nerve biopsy is considered as the gold standard for diagnosis but not a preferred choice, and magnetic resonance imaging has lower reported sensitivity. 18F-Fluorodeoxyglucose(18FDG) positron-emission tomography and computerized tomography(PET/CT) has a higher sensitivity for diagnosing and assessing the neurological and nonneurological metabolic tumor volume and response evaluation to therapy. We present the case of a lady, known to have NHL in remission. She presented with a short history of severe pain and weakness of the right lower limb. Baseline and interim 18FDG PET/CT played a crucial role in diagnosing and assessing the extent of NLS and nonneurological disease burden and also in evaluation of response to treatment.


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