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Fibrous dysplasia as a possible false-positive finding in 68Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancer

1 Department of Nuclear Medicine, A. C. Camargo Cancer Center, São Paulo, Brazil
2 Department of Urology, A. C. Camargo Cancer Center, São Paulo, Brazil

Correspondence Address:
André Marcondes Braga Ribeiro,
Department of Nuclear Medicine, A. C. Camargo Cancer Center, Rua Professor Antônio Prudente, 211, Liberdade, São Paulo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/wjnm.WJNM_111_18

Positron emission tomography/computed tomography (PET/CT) using 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA) has become an important tool in restaging patients with prostate cancer (PCa). Despite its high sensitivity and specificity, this method may produce false-positive findings, as indicated by previous studies. This case report aims to warn nuclear medicine physicians, oncologists, and urologists about the possibility of false-positive findings using this imaging modality, especially when the detected site is unusual for bone metastasis. A 68-year-old man with PCa underwent restaging tests after presenting with increased prostate-specific antigen. 68Ga-PSMA PET/CT imaging revealed abnormal uptake in the left humeral head, which anatomically corresponded to the intramedullary and cortical sclerotic area. A biopsy was performed, and the pathology showed a lesion consisting of hard bone tissue with a small focal spot of fibrous dysplasia. Diagnostic issues related to 68Ga-PSMA PET/CT imaging should be disseminated to help physicians make appropriate treatment choices for each patient.

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