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ORIGINAL ARTICLE
Year : 2020  |  Volume : 19  |  Issue : 1  |  Page : 1-7

Assessing oral glucose and intravenous insulin loading protocol in18F-fluorodeoxyglucose positron emission tomography cardiac viability studies


1 Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait
2 Department of Statistics, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait
3 Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey

Correspondence Address:
Dr. Ismet Sarikaya
Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, P. O. Box 24923, Safat, Kuwait City 13110
Kuwait
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DOI: 10.4103/wjnm.WJNM_58_18

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Oral glucose and intravenous insulin (G/I) loading protocols are commonly used in18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) cardiac viability studies. Although the amount of insulin to be given per blood glucose range has been well described in guidelines, the amount of glucose to be given is not detailed well. In this retrospective study, we aimed to assess if certain parameters, particularly the amount of glucose and insulin given, may affect18F-FDG uptake in the hibernating myocardium and also determine the problems with this protocol.18F-FDG PET cardiac viability study with G/I loading protocols was performed in 49 patients. Fasting blood glucose (FBG), amount of glucose given, blood glucose level after glucose load, amount of insulin given, and blood glucose level at the time of18F-FDG injection were recorded. Statistical analysis was performed to determine if there is any difference in the above values in PET viable and PET nonviable groups and also in subgroups assessing18F-FDG uptake also in normal myocardium. For G/I loading, we used our local protocol in 43 patients, and other protocols in six.18F-FDG PET showed viability in 31 patients, and it was negative for viability in 18. In 22 patients, mainly in PET viable group, there was varying degree of reduced18F-FDG uptake in normal myocardium. There was no significant difference in FBG, amount of glucose given, blood glucose level after glucose load, amount of insulin given, and blood glucose level at the time of18F-FDG injection in PET viable and PET nonviable groups and also in subgroups. The problems with G/I loading protocol included deciding on the amounts of glucose and insulin given, maximum amount of insulin to be given, handling diabetics, optimal time to measure blood glucose after insulin administration, and interpretation of findings in cases with diffusely reduced18F-FDG uptake. Further improvements in current guidelines are necessary to obtain images in optimal conditions for accurate results.


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