|Year : 2019 | Volume
| Issue : 4 | Page : 431-433
Metastatic large cell neuroendocrine carcinoma of larynx: Individualizing tumor biology by dual tracer positron emission tomography/computed tomography (68Ga-DOTATATE and18F-fluorodeoxyglucose) molecular imaging and disease stabilization following177Lu-DOTATATE peptide receptor radionuclide therapy after initial progression on chemoradiotherapy
Sonali Jadhav, Sandip Basu
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe; Homi Bhabha National Institute, Mumbai, Maharashtra, India
|Date of Submission||13-Sep-2018|
|Date of Acceptance||02-Dec-2018|
|Date of Web Publication||18-Dec-2019|
Dr. Sandip Basu
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital, Annexe Building, Jerbai Wadia Road, Parel, Mumbai, Maharashtra
| Abstract|| |
Debate exists on the disease biology and course of primary large cell neuroendocrine carcinoma (LCNEC) of larynx, being classified as a variant of atypical carcinoid by the World Health Organisation-2005 classification, while literature of its aggressive behavior indicating poorly differentiated neuroendocrine carcinoma (akin to pulmonary LCNEC) exists. The utility of dual tracer positron emission tomography/computed tomography (68Ga-DOTATATE and18F-fluorodeoxyglucose) in deciphering the dynamic tumor biology and feasibility of peptide receptor radionuclide therapy (PRRT) is illustrated in metastatic LCNEC of epiglottis after disease progression following conventional chemoradiotherapy. Relatively, atypical sites of soft-tissue metastases (subcutaneous tissue of arm, scrotal sac, peritoneum, and lamina of thyroid cartilage) and xiphisternum and disease stabilization following177 Lu-DOTATATE PRRT were other noteworthy unique aspects of this report.
Keywords: 177Lu-DOTATATE,18F-fluorodeoxyglucose,68Ga-DOTATATE, carcinoma larynx, dual tracer positron emission tomography-computed tomography, large cell neuroendocrine carcinoma, peptide receptor radionuclide therapy
|How to cite this article:|
Jadhav S, Basu S. Metastatic large cell neuroendocrine carcinoma of larynx: Individualizing tumor biology by dual tracer positron emission tomography/computed tomography (68Ga-DOTATATE and18F-fluorodeoxyglucose) molecular imaging and disease stabilization following177Lu-DOTATATE peptide receptor radionuclide therapy after initial progression on chemoradiotherapy. World J Nucl Med 2019;18:431-3
|How to cite this URL:|
Jadhav S, Basu S. Metastatic large cell neuroendocrine carcinoma of larynx: Individualizing tumor biology by dual tracer positron emission tomography/computed tomography (68Ga-DOTATATE and18F-fluorodeoxyglucose) molecular imaging and disease stabilization following177Lu-DOTATATE peptide receptor radionuclide therapy after initial progression on chemoradiotherapy. World J Nucl Med [serial online] 2019 [cited 2020 May 30];18:431-3. Available from: http://www.wjnm.org/text.asp?2019/18/4/431/267159
| Introduction|| |
The disease management and prognosis of the neuroendocrine tumors (NETs) is dependent on the histological subtype (determining tumor biology), site, and stage of the disease. Laryngeal NETs are the most common primary site among head and neck NETs, though comprising <1% of all laryngeal neoplasms. We herein describe a 60-year-old man of primary large cell neuroendocrine carcinoma (LCNEC) of epiglottis with atypical sites of metastases, who initially demonstrated progressive disease on conventional chemoradiotherapy, but subsequently showed disease stabilization following peptide receptor radionuclide therapy (PRRT) with177 Lu-DOTATATE.
| Case Report|| |
A 60-year-old man with a diagnosis of LCNEC of epiglottis with cervical nodal metastases (was staged as T2N1M0), underwent CO2 laser excision along with Left MND Type III). He received concurrent chemoradiotherapy (60 Gy/30#) and remained disease free for 20 months. Following relapsed with nodal metastasis, he was rechallanged with chemotherapy carboplatin and etoposide. The positron emission tomography-computed tomography (PET-CT) demonstrated stable disease post 6 cycles and was put on observation. Four months later, he presented with retrosternal pain and showed disease progression with a new lesion in sternum and was treated with 5 cycles of topotecan. At this time, he was considered for PRRT and underwent dual-tracer PET/CT with68 Ga-DOTATATE and fluorodeoxyglucose (FDG) for the same;68 Ga-DOTATATE PET-CT demonstrated high68 Ga-DOTATATE and low FDG uptake in the metastatic lesions, (i) sternum (maximum standardized uptake value [SUVmax] 58.13; 4.32), (ii) soft-tissue nodule over left lamina of thyroid cartilage (SUVmax 27.91; 4.89), (iii) subcutaneous nodule in right arm (SUVmax 15.32; 3.32), (iv) sub cm-sized nodule in the right scrotal sac, and (v) peritoneal deposit (SUV max 49.41; 12.35). He received PRRT with177 Lu-DOTATATE and following 2 cycles (cumulative dose: 12.506 GBq), he had a stable disease at 9 months and was worked up for 3rd cycle [Figure 1]a,[Figure 1]b, [Figure 2] and [Figure 3].
|Figure 1:68Ga-DOTATATE baseline and recent (post 2 cycles of peptide receptor radionuclide therapy) maximum intensity projection images (a) and fused transaxial images (b) of 3 prominent lesions|
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|Figure 2: Recent fluorodeoxyglucose-positron emission tomography [Figure 2] and the last177Lu-DOTATATE posttreatment scan [Figure 3] demonstrating lesions at the xiphisternum, lamina of thyroid cartilage subcutaneous tissue of the right arm, scrotal sac, and peritoneum|
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|Figure 3: The peritoneal deposit was not evident in the follow-up diagnostic scans [Figure 1 and 3] and the posttreatment scans [Figure 3] indicating complete metabolic response|
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| Discussion|| |
According to the 2005 World Health Organization (WHO) classification of head and neck tumors, NET of the larynx is divided into five histologic subtypes – typical carcinoid (TC), atypical carcinoid (AC), small cell NEC (SCNEC), combined small cell with non-small cell carcinoma, and paraganglioma. In the same classification system, primary laryngeal LCNEC had been considered as a variant of AC in contrast to the well-known pulmonary LCNEC which is categorized as poorly differentiated NECs. On the other hand, reports exist on its poor outcome emphasizing reclassification of LCNEC as variants of small cell carcinoma (poorly differentiated NEC)., In one report, patients of AC more often presented with Stage I and II disease while those with LCNEC presented with Stage III and IV disease. In the same meta-analysis, the 5-year disease-specific survival was found to be 100% for TC, 53% for AC, 19% for SCNEC, and 15% for LCNEC. Other authors have reported a favorable outcome of LCNEC indicating the possibility of a variant in LCNEC with comparatively slower disease course.[] Hence, there is a need for further exploring and studying its biology.[]
In the present case, interestingly, dual-tracer PET-CT demonstrated high-grade uptake on68 Ga-DOTATATE and low uptake on FDG commensurate with the WHO-2005 classification of LCNEC as a variant of AC. High avidity observed on68 Ga-DOTATATE (Krenning score-3) made177 Lu-DOTATATE-based PRRT a feasible treatment option, which resulted in disease stabilization of most of the lesions (complete response of peritoneal deposit) and no disease progression at the timing of writing this report at 9 months.
| Conclusion|| |
The described case underscores the potential role of dual tracer PET-CT molecular imaging in assessing the disease biology of metastatic lesions in LCNEC including indicating the feasibility of PRRT. SSTR-targeted68 Ga-DOTATATE PET-CT is a useful investigation in assessment, deciding on the feasibility of PRRT and follow-up akin to other NETs, while FDG uptake helps in prognosticating the disease. PRRT, in addition to concurrent chemo-radiotherapy, offers another potential therapeutic approach in receptor-positive cases of metastatic LCNEC and may result in longer survival.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Ferlito A, Silver CE, Bradford CR, Rinaldo A. Neuroendocrine neoplasms of the larynx: An overview. Head Neck 2009;31:1634-46.
Barnes EL, Eveson JW, Reichart P, Sidransky D, editors. Pathology and Genetics of Head and Neck Tumours. In: Kleihues P, Sobin LH, editors. World Health Organization Classification of Tumours. Lyon: IARC Press; 2005.
Lewis JS Jr., Spence DC, Chiosea S, Barnes EL Jr., Brandwein-Gensler M, El-Mofty SK, et al.
Large cell neuroendocrine carcinoma of the larynx: Definition of an entity. Head Neck Pathol 2010;4:198-207.
van der Laan TP, Plaat BE, van der Laan BF, Halmos GB. Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: A meta-analysis of 436 reported cases. Head Neck 2015;37:707-15.
Maithrea N, Ewe S, Pua KC, Mohamad I. Primary large cell neuroendocrine carcinoma of the larynx. Egypt J Ear Nose Throat Allied Sci 2017;18:179-81.
[Figure 1], [Figure 2], [Figure 3]