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ORIGINAL ARTICLE
Year : 2019  |  Volume : 18  |  Issue : 3  |  Page : 232-237

Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography compared with diagnostic computed tomography in relapsed prostate cancer


1 Department of Nuclear Medicine, Fiona Stanley Hospital, Murdoch, Australia
2 Theranostics Australia, East Fremantle, Australia
3 TeleMed Health Services, Busselton, Bussell Highway, West Busselton, Australia
4 Department of Nuclear Medicine, Fiona Stanley Hospital, Murdoch; Theranostics Australia, East Fremantle; Faculty of Health and Medical Sciences, UWA Medical School, Crawley, Australia
5 Nuclear Medicine, Perth Radiological Clinic, Nedlands, Western Australia, Australia

Correspondence Address:
Dr. Marcus Edward Asokendaran
Department of Nuclear Medicine, Sir Charles Gairdner Hospital, Level 1, G Block, Hospital Avenue, 6009, Nedlands, Western Australia
Australia
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DOI: 10.4103/wjnm.WJNM_59_18

PMID: 31516365

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The aim of this study was to evaluate if prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) has a higher detection rate compared to standard contrast CT imaging for patients with a rising prostate-specific antigen (PSA) following definitive treatment (i.e., curative radical prostatectomy, radiotherapy, and brachytherapy) for prostate cancer in a private hospital setting. A retrospective single-site clinical audit was conducted on 150 PSMA PET/CT scans done for patients with a rising PSA after definitive treatment for prostate cancer. All studies were performed using I and T Ga-68 PSMA produced on a Scintomics radiopharmaceutical unit (Munich). All scans were performed on a GE 710 PET/CT scanner. All studies were compared to standard CT and other imaging. Of the 150 patients who had a 68Gallium (Ga)-PSMA PET/CT for a rise in their PSA levels, 102/150 (68%) of patients had PSMA-avid scans compared to the conventional imaging group which had an overall detection rate of 42% (63/150). The rates of detection were 100%, 90%, 92%, 67%, and 25% at PSA levels of >10 μg/L, 5–10 μg/L, >1.5 μg/L, 0.5–1.5 μg/L, and <0.5 μg/L, respectively. PSMA PET/CT also solely picked up 39/102 (38%) of prostate cancer relapses compared to the conventional imaging group. In our study of 150 patients with biochemical recurrence of prostate cancer, 68Ga-PSMA PET/CT demonstrated a superior detection rate (P < 0.05) compared to conventional imaging, including patients with low PSA levels (<0.5 μg/L).


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