| ORIGINAL ARTICLE |
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| Year : 2017 | Volume
: 16
| Issue : 2 | Page : 140-144 |
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Initial clinical experience with 68Ga-DOTA-NOC prepared using 68Ga from nanoceria-polyacrylonitrile composite sorbent-based 68Ge/68Ga generator and freeze-dried DOTA-NOC kits
Piyush Chandra1, Bhakti Shetye1, Rubel Chakravarty2, Archana Mukherjee2, Usha Pandey2, Ashish Kumar Jha1, Nilendu Purandare1, Sneha Shah1, Archi Agrawal1, Ramu Ram2, Ashutosh Dash2, Venkatesh Rangarajan1
1 Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India
2 Isotope Production and Applications Division, Bhabha Atomic Research Centre, Trombay, Mumbai, Maharashtra, India
Correspondence Address:
Venkatesh Rangarajan
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, E. Borges Road, Parel, Mumbai - 400 012, Maharashtra
India
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DOI: 10.4103/1450-1147.203072 PMID: 28553181 
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Somatostatin receptor positron emission tomography–computed tomography (PET/CT) with 68Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) peptides have become an indispensable part of disease assessment in patients with neuroendocrine tumors and forms the basis of personalized therapy with peptide receptor-based radionuclide therapy. With growing utilization of PET/CT in developing countries, availability of the indigenous GMP-certified 68Ge/68Ga generators is expected to further promote cost-effective molecular imaging service to the cancer patients. We present our initial clinical experience in 32 patients injected with 68Ga-DOTA-NOC prepared using 68Ga eluted from Bhabha Atomic Research Centre nanoceria-polyacrylonitrile sorbent-based 68Ge/68Ga generator and freeze-dried DOTA-NOC cold kits.
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