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CASE REPORT
Year : 2015  |  Volume : 14  |  Issue : 3  |  Page : 212-215

Nuclear Medicine to Evaluate Complications of Cerebral Shunts: Two Cases and Review of Literature


1 Department of Radiology, University of South Alabama, Mobile, Alabama, USA
2 Department of Nephrology, University of South Alabama, Mobile, Alabama, USA

Date of Web Publication20-Aug-2015

Correspondence Address:
Dr. Beth Vettiyil
Department of Radiology, University of South Alabama Medical Center, 2451 Fillingim Street, Mobile, Alabama 36617
USA
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DOI: 10.4103/1450-1147.163263

PMID: 26420995

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   Abstract 

We present two cases of cerebral shunts - a ventriculopleural shunt and a ventriculoperitoneal shunt, with their associated complications. We also hope to provide a comprehensive literature review on various imaging modalities, including nuclear medicine studies in evaluating cerebral shunt complications.

Keywords: Abdominal cerebrospinal fluid oma, computed tomography in cerebrospinal fluid collection, cerebrospinal fluid pseudocyst, mass, nuclear medicine in cerebrospinal fluid pseudocyst, pleural effusion in ventriculopleural shunt, ultrasound in cerebrospinal fluid pseudocyst, ventriculoperitoneal shunt complications, ventriculopleural shunt


How to cite this article:
Vettiyil B, Bessette S, McQuiston S, Greiner F. Nuclear Medicine to Evaluate Complications of Cerebral Shunts: Two Cases and Review of Literature. World J Nucl Med 2015;14:212-5

How to cite this URL:
Vettiyil B, Bessette S, McQuiston S, Greiner F. Nuclear Medicine to Evaluate Complications of Cerebral Shunts: Two Cases and Review of Literature. World J Nucl Med [serial online] 2015 [cited 2019 Sep 19];14:212-5. Available from: http://www.wjnm.org/text.asp?2015/14/3/212/163263


   Introduction Top


Cerebral shunts are used for a variety of indications, including non communicating hydrocephalus, communicating hydrocephalus, spontaneous intracerebral hemorrhages and spontaneous subarachnoid hemorrhages. Different cerebral shunts are used, including ventriculoperitoneal, ventriculopleural, ventriculoatrial and ventriculourinary shunts. One of the main limiting factors in use of these shunts is the complications arising from them. The complications may be mechanical or functional.


   Case Reports Top


Case 1

Mr. A is a 16-year-old boy with congenital hydrocephalus who presented with left sided chest pain of 2 months duration. The chest pain was insidious in onset, progressive, and pressure-like. Initially, he had a ventriculoperitoneal (VP) shunt placed which drained into his peritoneal cavity. This shunt ruptured and was replaced with a ventriculopleural shunt that drained into his left pleural cavity [Figure 1]a and [Figure 1]b. The patient got a chest X-ray done, which showed a left-sided pleural effusion and left basilar atelectasis [Figure 2]. An ultrasound of his chest showed a large left pleural effusion without evidence of loculations [Figure 3]. Computed tomography (CT) scan of the chest confirmed the shunt in the left lower posterior pleural space with the pleural effusion [Figure 4]a-[Figure 4]c. A nuclear medicine scan was performed with technetium 99m MAA, which showed radiotracer uptake in the reservoir of the shunt and the left pleural space [Figure 5]. The patient was treated surgically with thoracentesis and continued to do well.
Figure 1: (a) Axial image of computed tomography scan of brain without contrast with dysmorphic lateral ventricles are noted with a shunt catheter in place in patient A. (b) Three-dimensional rendering from computed tomography images of the head of the cerebral shunt in patient A


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Figure 2: Anteroposterior plain radiograph of the chest depicting a ventriculopleural shunt, left pleural effusion and left basilar atelectasis


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Figure 3: Ultrasound image of the thorax depicting the left sided pleural effusion


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Figure 4: Computed tomography without contrast of the chest showing a left sided pleural effusion with the ventriculopleural shunt catheter entering the pleural cavity at the anterior apex of the lung and its tip in the left lower posterior pleural space. (a) Axial view. (b) Coronal view. (c) Sagittal view


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Figure 5: Nuclear medicine images with technetium 99m MAA. Planar images of the head and chest immediately after injection and delayed planar images. Radiotracer was seen throughout the left pleural space


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Case 2

Mr. B is 29-year-old male with a history of obstructive hydrocephalus, and a ventriculoperitonal shunt placement [Figure 6] came in with complaints of abdominal pain of 6 days duration with a 3 day history of nausea and vomiting. He had an abdominal X-ray which was inconclusive [Figure 7]. An ultrasound of his abdomen showed a large loculated, hypoechoic fluid collection extending from his xiphoid process to just below the umbilicus with a portion of the VP shunt inside [Figure 8]a and [Figure 8]b. He had a CT scan of his abdomen and pelvis which showed a large fluid collection containing a portion of the VP shunt inside [Figure 9]a and [Figure 9]b. He got a nuclear medicine scan with technetium diethylene-triamine-pentaacetate which showed ventriculomegaly and free spill of contrast into the peritoneal cavity [Figure 10]. The patient was treated surgically and got his VP shunt replaced with a ventriculoatrial shunt.
Figure 6: Computed tomography brain without contrast showing ventriculomegaly with an interventricular shunt. Also noted are callosal dysgenesis and absent septum pellucidum


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Figure 7: Plain radiograph of the abdomen depicting a nonobstructive gas pattern and the ventriculoperitoneal shunt in place


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Figure 8: Ultrasound images depicting a large hypoechoic fluid collection extending from the xiphoid process to just below the umbilicus. The collection appears loculated, measuring 27.9 cm × 15.4 cm × 22.5 cm and contains a portion of the ventriculopleural shunt inside. (a) Sagittal view. (b) Transverse view


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Figure 9: Computed tomography of the abdomen and pelvis with intravenous contrast depicting a fluid collection measuring 27.6 cm × 20.9 cm × 16.9 cm in the abdomen with a portion on the ventriculoperitoneal shunt inside. Also noted is the collapse of the inferior vena cava, likely secondary to the pseudocyst. (a) Axial view. (b) Coronal view


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Figure 10: Nuclear medicine images with 99m technetium diethylene-triamine-pentaacetate with ventriculomegaly and free spill of contrast into the peritoneal cavity at 90 min


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   Discussion Top


Cerebral shunts are used for a variety of indications. These include noncommunicating hydrocephalus, communicating hydrocephalus, spontaneous intracerebral hemorrhages, and spontaneous subarachnoid hemorrhages. [1] Cochrane and Kestle talk about three different locations for cerebral shunt placement-namely VP shunts, ventriculopleural shunts and ventriculoatrial shunts. [2] Less commonly, ventriculourinary shunts are used. The most commonly used shunt is a VP one. [1]

Ventriculoperitoneal shunts are preferred over the other routes due to various reasons, including ease of placement and lesser severity of potential complications. [3] The ventriculopleural shunts can be used as a temporary diversion in cases with contraindications to a VP shunt, until a definitive intracardiac shunt placement is done. [4] The contraindications may include recent abdominal infections. [5]

Overall shunt complications are seen in 24.6% of patients. [6] 45% of overall cerebral shunts require revision at some point of time. [7] VP shunts by themselves have been found to have a complication rate of 32% over a 5-year study period. [8]

Shunt complications can be divided as mechanical complications and functional complications. The mechanical complications include shunt obstruction, breaks, disconnections, migrations, or leakage. Functional complications can include infections, shunt over drainage, decompensated hydrocephalus, intracranial cyst formation, slit ventricle syndrome, cerebrospinal fluid (CSF) pseudocyst formation, or pleural effusions. [6],[7],[9]

Various diagnostic modalities can be used to evaluate cerebral shunts. Plain X-rays can evaluate shunt disconnections, kinks, breaks, or migration. CT can be used to confirm the findings and also to check for evidence of elevated intracranial pressure such as increased size of the ventricles. Magnetic resonance imaging can be used to evaluate central nervous system infections or hemorrhage. Nuclear studies can be used to evaluate shunt patency. Ultrasonography helps to evaluate the distal end of the shunt. Shunt studies with iodine injection can evaluate for leaks or confirm the site of obstruction. [9]

Overall, shunts have been found to have an infection rate of 8.6%. [2] Most cerebral shunt infections are seen in children 1-6 months of age. Two-thirds of these infections were found to be due to coagulase-negative Staphylococcus. [10]

Cerebrospinal fluid pseudocyst formation is one of the complications of a VP shunt. These are further complicated by bowel obstruction and infections. [9] Treatment options for abdominal pseudocyst include-treating infection if any, repositioning the catheter into the peritoneum, repositioning into pleural space, atrium or gallbladder; exploratory laparotomy with adhesion lysis and repositioning the catheter, abdominal pseudocyst aspiration, and shunt removal. [11] We describe a case of VP shunt in which an abdominal CSF pseudocyst was treated with surgical drainage and repositioning of the shunt into atria.

Ventriculopleural shunts can be complicated by minor pneumothoraces and less commonly pleural effusion. [5],[12] In our case of a ventriculopleural shunt, our patient developed a pleural effusion which was drained, and the patient did well.


   Acknowledgments Top


Kieran Murphy, MD for inspiring research.

 
   References Top

1.
Patwardhan RV, Nanda A. Implanted ventricular shunts in the United States: The billion-dollar-a-year cost of hydrocephalus treatment. Neurosurgery 2005;56:139-44.  Back to cited text no. 1
    
2.
Cochrane DD, Kestle J. Ventricular shunting for hydrocephalus in children: Patients, procedures, surgeons and institutions in English Canada, 1989-2001. Eur J Pediatr Surg 2002;12 Suppl 1:S6-11.  Back to cited text no. 2
    
3.
Lam CH, Villemure JG. Comparison between ventriculoatrial and ventriculoperitoneal shunting in the adult population. Br J Neurosurg 1997;11:43-8.  Back to cited text no. 3
    
4.
Willison CD, Kopitnik TA, Gustafson R, Kaufman HH. Ventriculopleural shunting used as a temporary diversion. Acta Neurochir (Wien) 1992;115:67-8.  Back to cited text no. 4
    
5.
Piatt JH Jr. How effective are ventriculopleural shunts? Pediatr Neurosurg 1994;21:66-70.  Back to cited text no. 5
    
6.
Brydon HL, Hayward R, Harkness W, Bayston R. Does the cerebrospinal fluid protein concentration increase the risk of shunt complications? Br J Neurosurg 1996;10:267-73.  Back to cited text no. 6
    
7.
Borgbjerg BM, Gjerris F, Albeck MJ, Hauerberg J, Børgesen SE. Frequency and causes of shunt revisions in different cerebrospinal fluid shunt types. Acta Neurochir (Wien) 1995;136:189-94.  Back to cited text no. 7
    
8.
Wu Y, Green NL, Wrensch MR, Zhao S, Gupta N. Ventriculoperitoneal shunt complications in California: 1990 to 2000. Neurosurgery 2007;61:557-62.  Back to cited text no. 8
    
9.
Goeser CD, McLeary MS, Young LW. Diagnostic imaging of ventriculoperitoneal shunt malfunctions and complications. Radiographics 1998;18:635-51.  Back to cited text no. 9
    
10.
Pople IK, Bayston R, Hayward RD. Infection of cerebrospinal fluid shunts in infants: A study of etiological factors. J Neurosurg 1992;77:29-36.  Back to cited text no. 10
    
11.
Mobley LW 3rd, Doran SE, Hellbusch LC. Abdominal pseudocyst: Predisposing factors and treatment algorithm. Pediatr Neurosurg 2005;41:77-83.  Back to cited text no. 11
    
12.
Küpeli E, Yilmaz C, Akçay S. Pleural effusion following ventriculopleural shunt: Case reports and review of the literature. Ann Thorac Med 2010;5:166-70.  Back to cited text no. 12
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8], [Figure 9], [Figure 10]


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[Pubmed] | [DOI]



 

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