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ORIGINAL ARTICLE
Year : 2014  |  Volume : 13  |  Issue : 2  |  Page : 128-131

Impact of the Point Spread Function on Maximum Standardized Uptake Value Measurements in Patients with Pulmonary Cancer


1 Department of Radiology, Toulouse University Hospital, Toulouse 31000, France
2 Department of Nuclear Medicine, Royal Free Hospital, London, NM3 2QG, United Kingdom
3 Department of PET/CT, Paul Strickland Scanner Centre, Northwood, Middlesex, HA6 2RN, United Kingdom
4 Department of Nuclear Medicine, Toulouse University Hospital, Toulouse 31000, France

Correspondence Address:
Dr. Thomas Wagner
Department of Nuclear Medicine, Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG
United Kingdom
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DOI: 10.4103/1450-1147.139144

PMID: 25191128

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Maximum standardized uptake value (SUVmax) from fluorodeoxyglucose (FDG) positron emission tomography (PET) scans is a semi quantitative measure that is increasingly used in the clinical practice for diagnostic and therapeutic response assessment purposes. Technological advances such as the implementation of the point spread function (PSF) in the reconstruction algorithm have led to higher signal to noise ratio and increased spatial resolution. The impact on SUVmax measurements has not been studied in clinical setting. We studied the impact of PSF on SUVmax in 30 consecutive lung cancer patients. SUVmax values were measured on PET-computed tomography (CT) scans reconstructed iteratively with and without PSF (respectively high-definition [HD] and non-HD). HD SUVmax values were significantly higher than non-HD SUVmax. There was excellent correlation between HD and non-HD values. Details of reconstruction and PSF implementation in particular have important consequences on SUV values. Nuclear Medicine physicians and radiologists should be aware of the reconstruction parameters of PET-CT scans when they report or rely on SUV measurements.


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