|Year : 2014 | Volume
| Issue : 1 | Page : 64-66
F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Rare Case of Recurrent Malignant Mixed Mullerian Tumor
Amit Bhoil, Raghava Kashyap, Anish Bhattacharya, Bhagwant Rai Mittal
Department of Nuclear Medicine and PET, Postgraduate Institute of Medical Education and Research, Chandigarh, India
|Date of Web Publication||12-Aug-2014|
Prof. Bhagwant Rai Mittal
Department of Nuclear Medicine and PET, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
| Abstract|| |
We report a case of 66-year-old female with previous history of histopathologically proven. Malignant mixed mullerain tumor of the uterus in whom positron emission tomography/computed tomography (CT) done for characterization of soft tissue lesion in pelvis noticed on CT, showed extensive recurrent disease in the pelvis with pulmonary metastases.
Keywords: Computed tomography, F-18 fluorodeoxyglucose, malignant mixed mullerian tumor recurrence, positron emission tomography/computed tomography, uterine carcinosarcoma
|How to cite this article:|
Bhoil A, Kashyap R, Bhattacharya A, Mittal BR. F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Rare Case of Recurrent Malignant Mixed Mullerian Tumor. World J Nucl Med 2014;13:64-6
|How to cite this URL:|
Bhoil A, Kashyap R, Bhattacharya A, Mittal BR. F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Rare Case of Recurrent Malignant Mixed Mullerian Tumor. World J Nucl Med [serial online] 2014 [cited 2020 Jul 4];13:64-6. Available from: http://www.wjnm.org/text.asp?2014/13/1/64/138578
| Introduction|| |
Malignant mixed mullerian tumors (MMMTs) or uterine carcinosarcomas are very uncommon and most lethal neoplasms.  They occur in postmenopausal women and comprise only 1-2% of uterine cancers and 3-5% of all uterine malignancies.  Clinical presentation usually consists of abdominal pain, distension, and atypical bleeding. Though common in the uterus, these tumors may also arise in the ovaries, fallopian tubes and vagina. ,,,, MMMT is composed of both epithelial (carcinoma) and mesenchymal (sarcoma) elements but the component responsible for its aggressive biological behavior remains unclear. , Survival rates for Stages I-III are dismal ranging from 33% to 39%, respectively.  Conventional imaging modalities, such as computed tomography (CT) and/or magnetic resonance imaging (MRI), have limited sensitivity in evaluation of recurrences, especially in asymptomatic patients.  Positron emission tomography/CT (PET/CT) may be a useful modality in the diagnosis of uterine sarcoma and recurrent disease.
| Case Report|| |
The case we present here is about a 66-year-old female with histopathologically proven carcinosarcoma of the uterus presented with the loss of appetite and generalized weakness. Patient had been previously treated with neo-adjuvant chemotherapy followed by total abdominal hysterectomy and bilateral salphingo-oopherectomy. Six cycles of adjuvant chemotherapy were also given. CT scan of the abdomen and pelvis showed a small soft tissue lesion in the region of the right adenxa. PET/CT performed for characterization of the soft tissue lesion and restaging of disease showed extensive recurrence in the pelvis extending to rectal sheath [Figure 1]a-c and pulmonary nodules indicative of metastases [Figure 1]d and e.
|Figure 1: (a-c) F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography images showing extensive FDG avidity in a soft tissue lesion in the pelvis extending to rectal sheath and (d and e) pulmonary nodules indicative of metastases|
Click here to view
| Discussion|| |
Uterine sarcomas are regarded as rare malignancies accounting for approximately 8% of uterine cancers, leiomyosarcoma and carcinosarcoma being the most common types.  Uterine carcinosarcomas, also known as MMMTs, are rare neoplasms and are associated with a dismal prognosis.  Worldwide roughly eight new cases/million women are reported every year.  Histologically, they contain both malignant epithelial and nonepithelial or sarcomatous components.  At 5-year survival data remain dismal for Stages I-III MMMT with several studies demonstrating survival rates ranging from 33% to 39%  with none reported in Stage IV.  MMMTs account for 16.4% of the deaths attributable to uterine malignancies. , Gynecologic Oncology Group study found that positive lymph nodes were a significant prognostic indicator in patients with uterine carcinosarcoma, but there is no consensus on the benefit of pelvic lymphadenectomy and the reported incidence of lymph node involvement varies widely.  Current surveillance strategy, consisting of physical examinations and conventional imaging modalities, such as CT and/or MRI, has limited sensitivity and cannot detect recurrences consistently, especially in asymptomatic patients.  PET/CT may be used for the diagnosis of uterine sarcoma and the differentiation of malignant and benign lesions.
Positron emission tomography/CT has shown high sensitivity of 87.5% and specificity of 97.5% for detecting disease in asymptomatic patients, and 92.9% and 100%, respectively for patients suspected of recurrence on CT.  PET imaging distinguishes true recurrence from postradiation alterations and morphologic changes not containing viable tumor cells, which may be interpreted as recurrence on conventional CT.  PET/CT has also been used to detect a uterine carcinosarcoma arising from an endometrial polyp.  Several studies have demonstrated that the sarcoma fluorodeoxyglucose (FDG) uptake level can be used to evaluate tumor response to treatment as FDG uptake is related to disease recurrence and to survival of patients with sarcomas.  The use of PET for uterine sarcoma can be extended with the use of other tracers such as C-11 choline, C-11 methionine, C-11 tyrosine, F-18 fluorotyrosine and F-18 fluorothymidine, all of which characterize tumor biology other than glucose metabolism.  C-11 choline has also been shown to be a good radiotracer for uterine carcinosarcoma.  PET is beneficial in excluding falsely inoperable disease as staged by MRI or CT and in making a decision on palliation for better quality-of-life.  It could be a useful modality for unexpected distant metastasis and followup tool in patients with MMMT.
| References|| |
|1.||Brooks SE, Zhan M, Cote T, Baquet CR. Surveillance, epidemiology, and end results analysis of 2677 cases of uterine sarcoma 1989-1999. Gynecol Oncol 2004;93:204-8. |
|2.||Robinson-Bennett B, Belch RZ, Han AC. Loss of p16 in recurrent malignant mixed müllerian tumors of the uterus. Int J Gynecol Cancer 2006;16:1354-7. |
|3.||Iwasa Y, Haga H, Konishi I, Kobashi Y, Higuchi K, Katsuyama E, et al. Prognostic factors in uterine carcinosarcoma: A clinicopathologic study of 25 patients. Cancer 1998;82:512-9. |
|4.||Navarini R, Pineda RL. Malignant mixed müllerian tumors of the ovary. Curr Opin Obstet Gynecol 2006;18:20-3. |
|5.||Garg G, Shah JP, Kumar S, Bryant CS, Munkarah A, Morris RT. Ovarian and uterine carcinosarcomas: A comparative analysis of prognostic variables and survival outcomes. Int J Gynecol Cancer 2010;20:888-94. |
|6.||Jin Z, Ogata S, Tamura G, Katayama Y, Fukase M, Yajima M, et al. Carcinosarcomas (malignant mullerian mixed tumors) of the uterus and ovary: A genetic study with special reference to histogenesis. Int J Gynecol Pathol 2003;22:368-73. |
|7.||Conner MG. Uncommon and relatively uncommon lesions of the female reproductive system. Adv Exp Med Biol 2005;563:10-20. |
|8.||Nemani D, Mitra N, Guo M, Lin L. Assessing the effects of lymphadenectomy and radiation therapy in patients with uterine carcinosarcoma: A SEER analysis. Gynecol Oncol 2008;111:82-8. |
|9.||Park JY, Kim EN, Kim DY, Suh DS, Kim JH, Kim YM, et al. Role of PET or PET/CT in the post-therapy surveillance of uterine sarcoma. Gynecol Oncol 2008;109:255-62. |
|10.||Chi DS, Mychalczak B, Saigo PE, Rescigno J, Brown CL. The role of whole-pelvic irradiation in the treatment of early-stage uterine carcinosarcoma. Gynecol Oncol 1997;65:493-8. |
|11.||Yoshida Y, Kurokawa T, Fukuno N, Nishikawa Y, Kamitani N, Kotsuji F. Markers of apoptosis and angiogenesis indicate that carcinomatous components play an important role in the malignant behavior of uterine carcinosarcoma. Hum Pathol 2000;31:1448-54. |
|12.||Gonzalez Bosquet J, Terstriep SA, Cliby WA, Brown-Jones M, Kaur JS, Podratz KC, et al. The impact of multi-modal therapy on survival for uterine carcinosarcomas. Gynecol Oncol 2010;116:419-23. |
|13.||Nieves-Lugo L, Blanch R, Abad M, Lilue M, Gómez C, Colmenter L, et al. Uterine carcinosarcoma arising from an endometrial polyp: Assessment by 3-dimensional power Doppler angiography and positron emission tomography/computed tomography. J Ultrasound Med 2006;25:675-8. |
|14.||Eary JF, O'Sullivan F, Powitan Y, Chandhury KR, Vernon C, Bruckner JD, et al. Sarcoma tumor FDG uptake measured by PET and patient outcome: A retrospective analysis. Eur J Nucl Med Mol Imaging 2002;29:1149-54. |
|15.||Torizuka T, Kanno T, Futatsubashi M, Okada H, Yoshikawa E, Nakamura F, et al. Imaging of gynecologic tumors: Comparison of (11) C-choline PET with (18) F-FDG PET. J Nucl Med 2003;44:1051-6. |
|16.||Ho KC, Lai CH, Wu TI, Ng KK, Yen TC, Lin G, et al. 18F-fluorodeoxyglucose positron emission tomography in uterine carcinosarcoma. Eur J Nucl Med Mol Imaging 2008;35:484-92. |